Formula Rationale of Vitamin D-3
Disclaimer:The information within is for educational purposes only and is not intended as medical advice.
The statements in this document have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent disease.
The authors and Innate Response Formulas®, a division of BioSan Laboratories Inc., disclaim any liability arising directly or indirect from the use of the information within.
Copyright©2007
Vitamin D-3 is a hormone that is naturally created by the skin with adequate sunlight (direct contact with the skin).The primary source of Vitamin D-3 is the sun. Vitamin D-3 is an important link to the sun’s life sustaining benefits. Together their energy touches every aspect of the physiology. Vitamin D-3 in conjunction with the sun affects cellular develop- ment,cell growth,cellular functions,cell to cell communication,gene expression,immune function,energy metabolism, muscle strength and coordination, neurotransmitter production, some types of inflammatory response and bone devel- opment.
The Benefits of Vitamin D-3
Breakthrough research on Vitamin D-3’s health benefits has created great excitement in the nutrition community. There is extensive evidence that Vitamin D-3’s importance to health goes far beyond the best known benefit. Vitamin D-3’s expanding range of therapeutic benefits includes so much more than bone building and enhancing calcium utilization.
Vitamin D-3
• Affects Muscle Strength and Coordination
• Maintains Tissue Function
• Affects Energy Production
• Affects Immune Function • Affects Gene Expression Vitamin D-3 affects Cell Development, Cell Growth and Cell Function
• Plays a role in Cell to Cell Communication
• Has been shown to be effective in Depression Therapies
• Has been shown to be effective in Autoimmune Disorder (MS) Therapies
• Has been shown to be effective in Therapeutic Cancer Programs
• Has been shown to be effective in Cancer Prevention Programs
• Has been shown to be effective in Lung Health Therapies
• Influences Nervous System Functions, central and peripheral, through its
modulation of Neuronal Calcium
Metabolism.*(ref. 15)
• Is involved in the creation of neurotransmitters. Vitamin D-3 possesses
anti-inflammatory properties and has been shown to be effective in Rheumatoid Arthritis therapies.* (ref. 16)
Vitamin D-3 Deficiency Symptoms
Too little active Vitamin D-3 can lead to or be a contributing factor in:psoriasis,osteoporosis,osteopenia,rickets,thyroid dysfunction,compromised immune function,hearing dysfunction,liver and kidney disorders,some forms of cancer,peri- odontal disease, cardiovascular disease and decreased insulin sensitivity. Vitamin D-3 Deficiency Factors
• Avoidance of exposure to the sun
• Use of sunscreens that interfere with D-3 production in the skin (sunscreens over 8 SPF reduce vitamin D production by 95%)(ref.9)
• Living in the North America especially on the Northern Coasts in the winter
• The elderly develop deficiencies with less exposure to the sun on a daily basis
• Aging diminishes Vitamin D synthesis
• Limited vegetarian and raw food sources of vitamin D
• Vitamin D in our food is degraded and catalyzed by light, heat and acids
• Decreased liver and kidney function reduce the ability to convert vitamin D to its active form
• Being overweight
• Mal absorption and digestive problems create difficulty converting vitamin D from food or sun into its active form.
• Low fat diets (healthy fats support vitamin D conversion and utilization)
• Vitamin D deficiency status varies with latitude.
• Dark Skin lessens vitamin D absorption through the skin, therefore African Americans are five times more likely to be deficient than Caucasians. (ref. 2)
Vitamin D-3 Dosage
Current research shows that the physiology’s requirements for Vitamin D-3 are higher than previously thought. Recent research indicates those who totally avoid the sun may require as much as 4,000 IU of Vitamin D-3 daily. It is estimat- ed that 20 minutes of direct summer sunlight, unfiltered by clothing, glass or sunscreens, enables the body to manufac- ture about 20,000 IU of vitamin D. This is much higher than the RDI/RDA set by the government. More research is needed to understand our varying requirements. Exposure to sunlight is an important factor to consider. Supplementation with 400 to 1000 IU is becoming common. Vitamin D-3 nutritional requirements will vary according to sun exposure, age, diet, and health. Most multiple vitamin and mineral supplements have vitamin D at 100-400 IU.
Vitamin D-3 Sources
The importance of Vitamin D-3 to health reinforces the importance of moderate daily exposure to direct sunlight on our quality of life. People in many parts of North America and at different stages of life, have limited exposure to direct, unfiltered sunlight on their skin. Aging contributes to the decline of the manufacture of Vitamin D-3 in the body. Some areas of the country have cloudy days, rain, snow, and cold weather that encourages people to cover their skin or stay indoors. Fear of skin cancer has people using sunscreens and avoiding sunlight exposure. We need 10-20 minutes of direct,unfiltered sunlight on our skin,3 or more times a week. This does not mean sunburn moderation is prudent. Those with darker skin produce less vitamin D in response to sunlight exposure. While some food is fortified with vitamin D (often in the less bioavailable form D-2) obtaining adequate quantities of Vitamin D from diet alone is difficult, espe- cially a vegetarian diet.
Sunshine and Vitamin D Creation
Vitamin D is produced in the skin following direct exposure to sunlight. When the ultraviolet light from the sun con- nects with the skins precholesterol molecules (7-dehydrocholesterol) these molecules become provitamin D. This com- pound it then converted in the liver to 25hydroxyvitamin D (25[OH]D). In the kidneys this intermediate vitamin D is transformed into the 1,25 dihydroxycholecalciferol molecule (D3 calcitrol or 1,25-dihydroxyvitamin D (1,25{OH]2D), the biologically active form. Vitamin D-3 is delivered in the biologically active form.
Vitamin D-3 and Bone Health
• Plays an important role in the treatment of osteoporosis and osteopenia.
• Is an essential part of a bone health and bone loss prevention program.
• Is a vital nutrient for healthy bone growth and development.
• In its active hormone form increases calcium and phosphorus absorption and utilization in the intestines.
• Helps maintain the balance of calcium and phosphorousin the blood and bone.
• Promotes calcium deposits in the matrix of the bone.
• Has revealed activity in the modulation of gene transcription directly affecting the bone. Vitamin D-3 supports bone
strength and therefore reduces the risk of fractures. (ref. 29)
Vitamin D-3 and Muscles, Mobility and Coordination
Research has found that strong muscles, good mobility and coordination have been associated with high levels of Vitamin D-3 in the blood. Vitamin D-3 deficiency is connected with muscle weakness. Studies have indicated that the muscle supporting action of vitamin D may contribute to a reduction in falls.
Vitamin D-3 and Pain
Several recent clinical studies have found that Vitamin D-3 deficiency is common in people with musculoskeletal pain. High dose Vitamin D-3 supplementation can reduce pain.
Vitamin D and Cancer Prevention
Studies have shown sufficient Vitamin D-3 levels are linked to a reduced risk of a variety of cancers. Vitamin D-3 is important for healthy cell growth and communication that reduces the risks for some types of cancer. The American Journal of Public HealthFebruary 2006, reports that researchers searched the Pub Med database and found 63 obser- vational studies of vitamin D status in relation to cancer risk dating from 1966 to 2004. Thirty of those studies focused on vitamin D and colon cancer, 13 on breast cancer, 26 on prostate cancer, and 7 on ovarian cancer. In addition, sever- al studies investigated whether mutations in vitamin D receptors are associated with an increased risk of cancer. After their review, the researchers concluded that the majority of the research found a protective relationship between suffi- cient vitamin D levels and lower risk of cancer. Most of the studies found that vitamin D could reduce cancer risk by up to 50 percent. Research on vitamin D and its cancer preventing properties is growing in volume and may indicate a need for adequate sunlight or supplementation.
Vitamin D and Autoimmune disorders
Research suggests that Vitamin D-3 plays a role in immune function. Autoimmune disorders such as MS are much less prevalent in countries near the equator, where there is greater exposure to sunlight and greater production of vitamin D. “Evidence suggests ultraviolet radiation (UVR) may play a protective role in three autoimmune diseases:multiple scle- rosis, insulin-dependent diabetes mellitus and rheumatoid arthritis.”(ref.28)
Conclusion
A nutrient that is as important to our physiology as vitamin D must be considered for any supplement program. Vitamin D3 is not prevalent in the diet. Supplementation is an important way to provide enough vitamin D-3 to support Optimal Health.
* These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
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